SEGUNDA DIVISIÓN 2010-2011 Jornada 22
| Pt | MP | W | D | L | F | A | GD | |||
| 1 | Real Betis Balompié | 46 | 22 | 14 | 4 | 4 | 46 | 21 | 25 | 1a |
| 2 | Rayo Vallecano | 46 | 22 | 14 | 4 | 4 | 38 | 21 | 17 | 1a |
| 3 | RC Celta | 44 | 22 | 12 | 8 | 2 | 41 | 20 | 21 | PO |
| 4 | Xerez CD | 35 | 22 | 10 | 5 | 7 | 33 | 29 | 4 | PO |
| 5 | Granada CF | 34 | 22 | 9 | 7 | 6 | 39 | 25 | 14 | PO |
| 6 | Villarreal CF B | 34 | 22 | 10 | 4 | 8 | 27 | 31 | -4 | PO |
| 7 | FC Barcelona B | 32 | 22 | 8 | 8 | 6 | 34 | 33 | 1 | |
| 8 | FC Cartagena | 32 | 22 | 9 | 5 | 8 | 31 | 31 | 0 | |
| 9 | CD Numancia | 30 | 22 | 9 | 3 | 10 | 32 | 29 | 3 | |
| 10 | Elche CF | 29 | 22 | 6 | 11 | 5 | 18 | 19 | -1 | |
| 11 | Córdoba CF | 28 | 22 | 6 | 10 | 6 | 29 | 28 | 1 | |
| 12 | SD Huesca | 28 | 22 | 6 | 10 | 6 | 16 | 20 | -4 | |
| 13 | Girona FC | 27 | 22 | 6 | 9 | 7 | 31 | 30 | 1 | |
| 14 | AD Alcorcón | 27 | 22 | 8 | 3 | 11 | 25 | 31 | -6 | |
| 15 | Real Valladolid | 26 | 22 | 7 | 5 | 10 | 28 | 30 | -2 | |
| 16 | UD Salamanca | 24 | 22 | 7 | 3 | 12 | 25 | 32 | -7 | |
| 17 | UD Las Palmas | 24 | 22 | 5 | 9 | 8 | 30 | 40 | -10 | |
| 18 | Recreativo Huelva | 23 | 22 | 4 | 11 | 7 | 20 | 23 | -3 | |
| 19 | Albacete Balompié | 23 | 22 | 5 | 8 | 9 | 18 | 24 | -6 | 2b |
| 20 | Gimnàstic Tarragona | 21 | 22 | 4 | 9 | 9 | 15 | 23 | -8 | 2b |
| 21 | CD Tenerife | 18 | 22 | 3 | 9 | 10 | 21 | 36 | -15 | 2b |
| 22 | SD Ponferradina | 18 | 22 | 3 | 9 | 10 | 17 | 38 | -21 | 2b |
| Jornada 21 « || Jornada 22 || » Jornada 23 |
SEGUNDA DIVISIÓN 2010-2011 Jornada 22
2011/01/28
| 21:00 | Municipal Santo Domingo | ||
| AD Alcorcón | 2-0 | Albacete Balompié |
| Javi Hernández 61' | 1-0 | |
| Nagore 90' | 2-0 | |
2011/01/29
| 16:00 | Nuevo Colombino | ||
| Recreativo Huelva | 0-0 | Elche CF |
| 18:00 | Cartagonova | ||
| FC Cartagena | 1-2 | Xerez CD |
| Víctor 22' | 1-0 | |
| 1-1 | 31' José Marí | |
| 1-2 | 65' José Marí | |
| 18:00 | Mini Estadi | ||
| FC Barcelona B | 1-1 | RC Celta |
| Eduardo Oriol 8' | 1-0 | |
| 1-1 | 63' Álex López | |
| 18:00 | Los Pajaritos | ||
| CD Numancia | 0-3 | Rayo Vallecano |
| 0-1 | 28' Míchel | |
| 0-2 | 45' Movilla | |
| 0-3 | 56' Míchel | |
| 18:00 | Nuevo Arcángel | ||
| Córdoba CF | 2-0 | UD Salamanca |
| Oriol 76' | 1-0 | |
| Pepe Díaz 84' | 2-0 | |
| 18:00 | Nou Estadi | ||
| Gimnàstic Tarragona | 0-0 | UD Las Palmas |
| 18:00 | El Alcoraz | ||
| SD Huesca | 1-0 | SD Ponferradina |
| Camacho 90' | 1-0 | |
| 18:00 | Ciudad Deportiva | ||
| Villarreal CF B | 2-0 | Real Valladolid |
| N.Bille Nielsen 30' | 1-0 | |
| Marquitos 90' | 2-0 | |
2011/01/30
| 12:00 | Estadio Los Cármenes | ||
| Granada CF | 3-0 | Real Betis Balompié |
| Alex Geijo 52' | 1-0 | |
| Dani Benítez 59' | 2-0 | |
| Alex Geijo 64' | 3-0 | |
| 18:00 | Heliodoro Rodríguez López | ||
| CD Tenerife | 3-3 | Girona FC |
| Pablo Sicilia 14' | 1-0 | |
| 1-1 | 31' R.Despotović | |
| 1-2 | 41' R.Despotović | |
| 1-3 | 60' Kiko Ratón | |
| Nino 61' | 2-3 | |
| Nino 90' | 3-3 | |