SEGUNDA DIVISIÓN 2010-2011 Jornada 21
| Pt | MP | W | D | L | F | A | GD | |||
| 1 | Real Betis Balompié | 46 | 21 | 14 | 4 | 3 | 46 | 18 | 28 | 1a |
| 2 | RC Celta | 43 | 21 | 12 | 7 | 2 | 40 | 19 | 21 | 1a |
| 3 | Rayo Vallecano | 43 | 21 | 13 | 4 | 4 | 35 | 21 | 14 | PO |
| 4 | Xerez CD | 32 | 21 | 9 | 5 | 7 | 31 | 28 | 3 | PO |
| 5 | FC Cartagena | 32 | 21 | 9 | 5 | 7 | 30 | 29 | 1 | PO |
| 6 | Granada CF | 31 | 21 | 8 | 7 | 6 | 36 | 25 | 11 | PO |
| 7 | FC Barcelona B | 31 | 21 | 8 | 7 | 6 | 33 | 32 | 1 | |
| 8 | Villarreal CF B | 31 | 21 | 9 | 4 | 8 | 25 | 31 | -6 | |
| 9 | CD Numancia | 30 | 21 | 9 | 3 | 9 | 32 | 26 | 6 | |
| 10 | Elche CF | 28 | 21 | 6 | 10 | 5 | 18 | 19 | -1 | |
| 11 | Girona FC | 26 | 21 | 6 | 8 | 7 | 28 | 27 | 1 | |
| 12 | Real Valladolid | 26 | 21 | 7 | 5 | 9 | 28 | 28 | 0 | |
| 13 | Córdoba CF | 25 | 21 | 5 | 10 | 6 | 27 | 28 | -1 | |
| 14 | SD Huesca | 25 | 21 | 5 | 10 | 6 | 15 | 20 | -5 | |
| 15 | UD Salamanca | 24 | 21 | 7 | 3 | 11 | 25 | 30 | -5 | |
| 16 | AD Alcorcón | 24 | 21 | 7 | 3 | 11 | 23 | 31 | -8 | |
| 17 | Albacete Balompié | 23 | 21 | 5 | 8 | 8 | 18 | 22 | -4 | |
| 18 | UD Las Palmas | 23 | 21 | 5 | 8 | 8 | 30 | 40 | -10 | |
| 19 | Recreativo Huelva | 22 | 21 | 4 | 10 | 7 | 20 | 23 | -3 | 2b |
| 20 | Gimnàstic Tarragona | 20 | 21 | 4 | 8 | 9 | 15 | 23 | -8 | 2b |
| 21 | SD Ponferradina | 18 | 21 | 3 | 9 | 9 | 17 | 37 | -20 | 2b |
| 22 | CD Tenerife | 17 | 21 | 3 | 8 | 10 | 18 | 33 | -15 | 2b |
| Jornada 20 « || Jornada 21 || » Jornada 22 |
SEGUNDA DIVISIÓN 2010-2011 Jornada 21
2011/01/21
| 21:00 | Estadio Municipal de Chapín | ||
| Xerez CD | 0-0 | Elche CF |
2011/01/22
| 16:00 | Municipal Santo Domingo | ||
| AD Alcorcón | 1-0 | Real Valladolid |
| Quini 74' | 1-0 | |
| 18:00 | Estadio Los Cármenes | ||
| Granada CF | 2-1 | Recreativo Huelva |
| 0-1 | 36' Jesús Vázquez (pen) | |
| F.Orellana 56' | 1-1 | |
| Diego Mainz 88' | 2-1 | |
| 18:00 | Ciudad Deportiva | ||
| Villarreal CF B | 1-0 | Real Betis Balompié |
| Iago Falque (pen) 4' | 1-0 | |
| 18:00 | El Alcoraz | ||
| SD Huesca | 1-0 | Albacete Balompié |
| Camacho 38' | 1-0 | |
| 18:00 | Mini Estadi | ||
| FC Barcelona B | 1-2 | Rayo Vallecano |
| 0-1 | 1' Ó.Trejo | |
| Soriano 35' | 1-1 | |
| 1-2 | 68' E.Armenteros | |
| 18:00 | Cartagonova | ||
| FC Cartagena | 0-4 | RC Celta |
| 0-1 | 8' David Rodriguez | |
| 0-2 | 41' Michu | |
| 0-3 | 60' Roberto Trashorras | |
| 0-4 | 82' Michu | |
2011/01/23
| 12:00 | Heliodoro Rodríguez López | ||
| CD Tenerife | 1-1 | UD Las Palmas |
| Melli 51' | 1-0 | |
| 1-1 | 87' M.Quiroga | |
| 17:00 | Nou Estadi | ||
| Gimnàstic Tarragona | 0-0 | SD Ponferradina |
| 17:00 | Nuevo Arcángel | ||
| Córdoba CF | 1-1 | Girona FC |
| 0-1 | 80' Kiko Ratón | |
| Arteaga 89' | 1-1 | |
| 17:00 | Los Pajaritos | ||
| CD Numancia | 3-2 | UD Salamanca |
| Jaio 43' | 1-0 | |
| Barkero (pen) 51' | 2-0 | |
| 2-1 | 59' Kike | |
| 2-2 | 90' Kike | |
| Dimas 90' | 3-2 | |