PRIMERA DIVISIÓN 2015-2016 Jornada 21
| Pt | MP | W | D | L | F | A | GD | |||
| 1 | FC Barcelona | 51 | 21 | 16 | 3 | 2 | 55 | 17 | 38 | UCL |
| 2 | Atlético de Madrid | 48 | 21 | 15 | 3 | 3 | 30 | 8 | 22 | UCL |
| 3 | Real Madrid | 44 | 21 | 13 | 5 | 3 | 58 | 20 | 38 | UCL |
| 4 | Villarreal CF | 41 | 21 | 12 | 5 | 4 | 28 | 18 | 10 | UCL |
| 5 | RC Celta | 34 | 21 | 10 | 4 | 7 | 32 | 33 | -1 | UEL |
| 6 | SD Eibar | 33 | 21 | 9 | 6 | 6 | 34 | 26 | 8 | UEL |
| 7 | Sevilla FC | 33 | 21 | 9 | 6 | 6 | 28 | 22 | 6 | |
| 8 | Athletic Club | 31 | 21 | 9 | 4 | 8 | 32 | 30 | 2 | |
| 9 | RC Deportivo | 29 | 21 | 6 | 11 | 4 | 28 | 25 | 3 | |
| 10 | Getafe CF | 26 | 21 | 7 | 5 | 9 | 26 | 31 | -5 | |
| 11 | Valencia CF | 25 | 21 | 5 | 10 | 6 | 26 | 22 | 4 | |
| 12 | Málaga CF | 24 | 21 | 6 | 6 | 9 | 16 | 19 | -3 | |
| 13 | RCD Espanyol | 22 | 21 | 6 | 4 | 11 | 20 | 35 | -15 | |
| 14 | Real Betis Balompié | 22 | 21 | 5 | 7 | 9 | 14 | 29 | -15 | |
| 15 | Real Sociedad | 21 | 21 | 5 | 6 | 10 | 24 | 33 | -9 | |
| 16 | Granada CF | 20 | 21 | 5 | 5 | 11 | 24 | 43 | -19 | |
| 17 | Rayo Vallecano | 19 | 21 | 5 | 4 | 12 | 26 | 45 | -19 | |
| 18 | UD Las Palmas | 18 | 21 | 4 | 6 | 11 | 21 | 33 | -12 | 2a |
| 19 | Sporting Gijón | 18 | 21 | 5 | 3 | 13 | 23 | 38 | -15 | 2a |
| 20 | Levante UD | 17 | 21 | 4 | 5 | 12 | 20 | 38 | -18 | 2a |
| Jornada 20 « || Jornada 21 || » Jornada 22 |
PRIMERA DIVISIÓN 2015-2016 Jornada 21
2016/01/22
| 20:30 | El Molinón | ||
| Sporting Gijón | 5-1 | Real Sociedad |
| Carlos Carmona 1' | 1-0 | |
| D.N'Di 9' | 2-0 | |
| 2-1 | 37' C.Vela | |
| A.Sanabria 44' | 3-1 | |
| A.Sanabria 53' | 4-1 | |
| A.Sanabria 81' | 5-1 | |
2016/01/23
| 16:00 | La Rosaleda | ||
| Málaga CF | 1-2 | FC Barcelona |
| 0-1 | 2' Munir El Haddadi | |
| J.Añor 32' | 1-1 | |
| 1-2 | 51' L.Messi | |
| 18:15 | Cornellà-El Prat | ||
| RCD Espanyol | 2-2 | Villarreal CF |
| F.Caicedo 4' | 1-0 | |
| 1-1 | 24' Trigueros | |
| Gerard Moreno 40' | 2-1 | |
| 2-2 | 88' M.Musacchio | |
| 20:30 | Nuevo Los Cármenes | ||
| Granada CF | 3-2 | Getafe CF |
| Fran Rico 27' | 1-0 | |
| Y.El-Arabi 36' | 2-0 | |
| 2-1 | 71' S.Šćepović | |
| 2-2 | 74' Moi Gómez | |
| Rubén Rochina 77' | 3-2 | |
| 22:05 | Campo de Vallecas | ||
| Rayo Vallecano | 3-0 | RC Celta |
| N.Fedor 21' | 1-0 | |
| Tito 26' | 2-0 | |
| Jozabed 36' | 3-0 | |
2016/01/24
| 12:00 | San Mamés Barria | ||
| Athletic Club | 5-2 | SD Eibar |
| 0-1 | 4' Borja Bastón | |
| Aduriz 12' | 1-1 | |
| Sabin 27' | 2-1 | |
| A.Laporte 40' | 3-1 | |
| 3-2 | 50' Borja Bastón (pen) | |
| Aduriz 52' | 4-2 | |
| OG (M.dos Santos) 80' | 5-2 | |
| 16:00 | Vicente Calderón | ||
| Atlético de Madrid | 0-0 | Sevilla FC |
| 18:15 | Riazor | ||
| RC Deportivo | 1-1 | Valencia CF |
| Lucas Pérez 27' | 1-0 | |
| 1-1 | 90+3' Álvaro Negredo | |
| 20:30 | Benito Villamarín | ||
| Real Betis Balompié | 1-1 | Real Madrid |
| Cejudo 7' | 1-0 | |
| 1-1 | 71' K.Benzema | |
2016/01/25
| 20:30 | Ciutat de València | ||
| Levante UD | 3-2 | UD Las Palmas |
| José Luis Morales 25' | 1-0 | |
| Deyverson 47' | 2-0 | |
| 2-1 | 49' Willian José | |
| José Luis Morales 63' | 3-1 | |
| 3-2 | 66' Willian José | |