MAJOR LEAGUE SOCCER 2021
| EASTERN CONFERENCE | Pt | MP | W | D | L | F | A | GD | ||
| 1 | New England Revolution | 17 | 8 | 5 | 2 | 1 | 11 | 7 | 4 | FS |
| 2 | Philadelphia Union | 14 | 8 | 4 | 2 | 2 | 9 | 5 | 4 | PO |
| 3 | Orlando City | 12 | 7 | 3 | 3 | 1 | 8 | 4 | 4 | PO |
| 4 | New York City | 11 | 7 | 3 | 2 | 2 | 13 | 7 | 6 | PO |
| 5 | CF Montréal | 11 | 8 | 3 | 2 | 3 | 10 | 9 | 1 | PO |
| 6 | Columbus Crew | 11 | 7 | 3 | 2 | 2 | 7 | 6 | 1 | PO |
| 7 | Nashville SC | 11 | 7 | 2 | 5 | 0 | 9 | 6 | 3 | PO |
| 8 | Atlanta United | 10 | 7 | 2 | 4 | 1 | 9 | 7 | 2 | |
| 9 | New York Red Bulls | 9 | 7 | 3 | 0 | 4 | 10 | 10 | 0 | |
| 10 | D.C. United | 9 | 8 | 3 | 0 | 5 | 8 | 11 | -3 | |
| 11 | Inter Miami | 8 | 8 | 2 | 2 | 4 | 8 | 13 | -5 | |
| 12 | Toronto FC | 5 | 7 | 1 | 2 | 4 | 8 | 12 | -4 | |
| 13 | Chicago Fire | 4 | 7 | 1 | 1 | 5 | 4 | 11 | -7 | |
| 14 | FC Cincinnati | 4 | 6 | 1 | 1 | 4 | 6 | 15 | -9 | |
| WESTERN CONFERENCE | Pt | MP | W | D | L | F | A | GD | ||
| 1 | Seattle Sounders | 18 | 8 | 5 | 3 | 0 | 14 | 3 | 11 | FS |
| 2 | Sporting Kansas City | 16 | 8 | 5 | 1 | 2 | 15 | 10 | 5 | PO |
| 3 | Los Angeles Galaxy | 15 | 7 | 5 | 0 | 2 | 11 | 11 | 0 | PO |
| 4 | Colorado Rapids | 13 | 7 | 4 | 1 | 2 | 12 | 8 | 4 | PO |
| 5 | Houston Dynamo | 11 | 8 | 3 | 2 | 3 | 11 | 12 | -1 | PO |
| 6 | San Jose Earthquakes | 9 | 8 | 3 | 0 | 5 | 11 | 12 | -1 | PO |
| 7 | Portland Timbers | 9 | 7 | 3 | 0 | 4 | 9 | 11 | -2 | PO |
| 8 | Real Salt Lake | 9 | 6 | 2 | 3 | 1 | 9 | 7 | 2 | |
| 9 | Los Angeles FC | 8 | 7 | 2 | 2 | 3 | 8 | 9 | -1 | |
| 10 | Vancouver Whitecaps | 7 | 7 | 2 | 1 | 4 | 6 | 9 | -3 | |
| 11 | Austin FC | 7 | 7 | 2 | 1 | 4 | 5 | 8 | -3 | |
| 12 | Minnesota United | 7 | 7 | 2 | 1 | 4 | 6 | 11 | -5 | |
| 13 | FC Dallas | 6 | 7 | 1 | 3 | 3 | 8 | 11 | -3 |
| 2021/05/22 « || 2021/05/28 || » 2021/06/12 |
MAJOR LEAGUE SOCCER 2021
2021/05/29
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13:00 | Red Bull Arena
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| New York Red Bulls | 2-1 | Orlando City | |||||||||
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12:00 | Soldier Field
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| Chicago Fire | 0-1 | CF Montréal | |||
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15:00 | West End Stadium
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| FC Cincinnati | 0-1 | New England Revolution | |||
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15:00 | New Columbus Crew Stadium
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| Columbus Crew | 2-1 | Toronto FC | |||||||||
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15:30 | Mercedes-Benz Stadium
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| Atlanta United | 2-2 | Nashville SC | ||||||||||||
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14:00 | Banc of California Stadium
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| Los Angeles FC | 1-2 | New York City | |||||||||
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16:00 | Dignity Health Sports Park
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| Los Angeles Galaxy | 1-0 | San Jose Earthquakes | |||
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20:00 | Inter Miami Stadium
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| Inter Miami | 0-3 | D.C. United | |||||||||
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19:30 | Children's Mercy Park
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| Sporting Kansas City | 3-2 | Houston Dynamo | |||||||||||||||
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19:00 | Dick's Sporting Goods Park
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| Colorado Rapids | 3-0 | FC Dallas | |||||||||
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19:30 | Rio Tinto Stadium
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| Real Salt Lake | 1-1 | Minnesota United | ||||||
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2021/05/30
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19:00 | Subaru Park
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| Philadelphia Union | 3-0 | Portland Timbers | |||||||||
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18:30 | Lumen Field
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| Seattle Sounders | 0-0 | Austin FC |