MAJOR LEAGUE SOCCER 2021
| EASTERN CONFERENCE | Pt | MP | W | D | L | F | A | GD | ||
| 1 | New York City | 7 | 4 | 2 | 1 | 1 | 9 | 3 | 6 | FS |
| 2 | New England Revolution | 7 | 4 | 2 | 1 | 1 | 5 | 5 | 0 | PO |
| 3 | Orlando City | 6 | 4 | 1 | 3 | 0 | 5 | 2 | 3 | PO |
| 4 | New York Red Bulls | 6 | 4 | 2 | 0 | 2 | 7 | 5 | 2 | PO |
| 5 | Nashville SC | 6 | 4 | 1 | 3 | 0 | 6 | 4 | 2 | PO |
| 6 | Columbus Crew | 5 | 3 | 1 | 2 | 0 | 3 | 1 | 2 | PO |
| 7 | Atlanta United | 5 | 4 | 1 | 2 | 1 | 5 | 4 | 1 | PO |
| 8 | CF Montréal | 5 | 4 | 1 | 2 | 1 | 6 | 6 | 0 | |
| 9 | Inter Miami | 5 | 4 | 1 | 2 | 1 | 5 | 5 | 0 | |
| 10 | Philadelphia Union | 4 | 4 | 1 | 1 | 2 | 3 | 4 | -1 | |
| 11 | D.C. United | 3 | 4 | 1 | 0 | 3 | 4 | 9 | -5 | |
| 12 | Toronto FC | 1 | 3 | 0 | 1 | 2 | 4 | 8 | -4 | |
| 13 | Chicago Fire | 1 | 4 | 0 | 1 | 3 | 3 | 9 | -6 | |
| 14 | FC Cincinnati | 1 | 3 | 0 | 1 | 2 | 2 | 10 | -8 | |
| WESTERN CONFERENCE | Pt | MP | W | D | L | F | A | GD | ||
| 1 | Seattle Sounders | 10 | 4 | 3 | 1 | 0 | 10 | 2 | 8 | FS |
| 2 | San Jose Earthquakes | 9 | 4 | 3 | 0 | 1 | 10 | 5 | 5 | PO |
| 3 | Los Angeles Galaxy | 9 | 4 | 3 | 0 | 1 | 8 | 8 | 0 | PO |
| 4 | Vancouver Whitecaps | 7 | 4 | 2 | 1 | 1 | 5 | 3 | 2 | PO |
| 5 | Sporting Kansas City | 7 | 4 | 2 | 1 | 1 | 6 | 6 | 0 | PO |
| 6 | Colorado Rapids | 7 | 4 | 2 | 1 | 1 | 5 | 5 | 0 | PO |
| 7 | Real Salt Lake | 6 | 3 | 2 | 0 | 1 | 6 | 4 | 2 | PO |
| 8 | Austin FC | 6 | 4 | 2 | 0 | 2 | 5 | 5 | 0 | |
| 9 | FC Dallas | 5 | 4 | 1 | 2 | 1 | 6 | 5 | 1 | |
| 10 | Los Angeles FC | 5 | 4 | 1 | 2 | 1 | 5 | 4 | 1 | |
| 11 | Houston Dynamo | 5 | 4 | 1 | 2 | 1 | 5 | 5 | 0 | |
| 12 | Portland Timbers | 3 | 4 | 1 | 0 | 3 | 4 | 8 | -4 | |
| 13 | Minnesota United | 0 | 4 | 0 | 0 | 4 | 3 | 10 | -7 |
| 2021/05/01 « || 2021/05/07 || » 2021/05/11 |
MAJOR LEAGUE SOCCER 2021
2021/05/07
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19:30 | Rio Tinto Stadium
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| Real Salt Lake | 1-2 | San Jose Earthquakes | |||||||||
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2021/05/08
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12:00 | Soldier Field
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| Chicago Fire | 0-2 | Philadelphia Union | ||||||
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13:00 | Red Bull Arena
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| New York Red Bulls | 2-0 | Toronto FC | ||||||
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12:30 | Nissan Stadium
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| Nashville SC | 2-0 | New England Revolution | ||||||
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13:30 | New Columbus Crew Stadium
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| Columbus Crew | 3-1 | D.C. United | ||||||||||||
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12:00 | BC Place
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| Vancouver Whitecaps | 2-0 | CF Montréal | ||||||
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14:30 | Toyota Stadium
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| FC Dallas | 1-1 | Houston Dynamo | ||||||
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18:00 | Exploria Stadium
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| Orlando City | 1-1 | New York City | ||||||
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17:00 | Dignity Health Sports Park
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| Los Angeles Galaxy | 2-1 | Los Angeles FC | |||||||||
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20:00 | Dick's Sporting Goods Park
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| Colorado Rapids | 3-2 | Minnesota United | |||||||||||||||
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2021/05/09
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13:00 | Inter Miami Stadium
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| Inter Miami | 1-1 | Atlanta United | ||||||
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12:00 | Providence Park
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| Portland Timbers | 1-2 | Seattle Sounders | |||||||||
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18:30 | Children's Mercy Park
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| Sporting Kansas City | 2-1 | Austin FC | |||||||||
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